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516481 Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem

Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid

Primary Target: cathepsin D
516481
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
26305-03-3C₃₄H₆₃N₅O₉

Products

Número de referenciaEmbalaje Cant./Env.
516481-100MG Ampolla de plást. 100 mg
516481-25MG Ampolla de plást. 25 mg
516481-5MG Ampolla de plást. 5 mg
Description
OverviewA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437).
Effective concentration: 1.0 µM.
Catalogue Number516481
Brand Family Calbiochem®
SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
References
ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.
Product Information
CAS number26305-03-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₄H₆₃N₅O₉
Chemical formulaC₃₄H₆₃N₅O₉
Optical rotationOptical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin D
Primary Target IC<sub>50</sub>EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSSC6155000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
516481-100MG 04055977198812
516481-25MG 07790788055837
516481-5MG 04055977198836

Documentation

Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Certificados de análisis

CargoNúmero de lote
516481

Referencias bibliográficas

Visión general referencias
Isahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.

Folleto

Cargo
Western Blotting Tools

Licencias necesarias e Información técnica

Cargo
Protein Blotting Handbook: 6th Edition
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-October-2013 JSW
SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
DescriptionA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cells. Effective concentration: 1 µM.
FormWhite solid
Recommended reaction conditions
Activity:
Activity is measured by inhibition of pepsin. 1 U corresponds to the amount of inhibitor that reduces the activity of pepsin by 1 U (1 U of enzyme corresponds to the amount of enzyme that results in the increases the absorbance at 280 nm by 0.001 per min at pH 2.0, 37°C.)
CAS number26305-03-3
RTECSSC6155000
Chemical formulaC₃₄H₆₃N₅O₉
Purity≥98% by HPLC
SolubilityDMSO (1 mg/ml) or Methanol (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 7147
ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.