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512732 Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem

A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
512732
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
20554-84-1C₁₅H₂₀O₃

Products

Número de referenciaEmbalaje Cant./Env.
512732-50MG Ampolla de plást. 50 mg
Description
OverviewA cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
Catalogue Number512732
Brand Family Calbiochem®
References
ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
Product Information
CAS number20554-84-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₂₀O₃
Chemical formulaC₁₅H₂₀O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetthe expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLY4220000
Safety Information
R PhraseR: 20/21/22-40-42/43

Harmful by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
May cause sensitization by inhalation and skin contact.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
512732-50MG 04055977272079

Documentation

Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem Certificados de análisis

CargoNúmero de lote
512732

Referencias bibliográficas

Visión general referencias
Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2021 JSW
DescriptionA sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
FormWhite solid
CAS number20554-84-1
RTECSLY4220000
Chemical formulaC₁₅H₂₀O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml) or ethanol (20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.