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539741 PTP1B Inhibitor - CAS 765317-72-4 - Calbiochem

PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII

Primary Target: PTP1B403
539741
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
765317-72-4C₂₆H₁₉Br₂N₃O₇S₃

Products

Número de referenciaEmbalaje Cant./Env.
539741-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable sulfanamido-benzbromarone compound that acts as a selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution™ format (Cat. No. 539749).
Catalogue Number539741
Brand Family Calbiochem®
Synonyms3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII
References
ReferencesWiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.
Product Information
CAS number765317-72-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₆H₁₉Br₂N₃O₇S₃
Chemical formulaC₂₆H₁₉Br₂N₃O₇S₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPTP1B403
Primary Target IC<sub>50</sub> 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
539741-5MG 04055977194302

Documentation

PTP1B Inhibitor - CAS 765317-72-4 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

PTP1B Inhibitor - CAS 765317-72-4 - Calbiochem Certificados de análisis

CargoNúmero de lote
539741

Referencias bibliográficas

Visión general referencias
Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-January-2012 RFH
Synonyms3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII
DescriptionA cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution™ format (Cat. No. 539749.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number765317-72-4
Chemical formulaC₂₆H₁₉Br₂N₃O₇S₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.