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529599 PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem

529599
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
956026-24-7C₁₈H₂₃N₅

Products

Número de referenciaEmbalaje Cant./Env.
529599-10MG Frasco de vidrio 10 mg
Description
OverviewA cell-permeable 3-MB-PP1 (Cat. No. 529582) analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1 µM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells.
Catalogue Number529599
Brand Family Calbiochem®
SynonymsSyk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
References
ReferencesMiller, A.L., et al. 2009. J. Immunol. 182, 988.
Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.
Product Information
CAS number956026-24-7
FormOff-white powder
Hill FormulaC₁₈H₂₃N₅
Chemical formulaC₁₈H₂₃N₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
529599-10MG 04055977269925

Documentation

PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem Certificados de análisis

CargoNúmero de lote
529599

Referencias bibliográficas

Visión general referencias
Miller, A.L., et al. 2009. J. Immunol. 182, 988.
Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2012 JSW
SynonymsSyk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
DescriptionA cell-permeable 3-MB-PP1 (Cat. No. 529582) analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1 µM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number956026-24-7
Chemical formulaC₁₈H₂₃N₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMiller, A.L., et al. 2009. J. Immunol. 182, 988.
Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.