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527455 PKR Inhibitor, Negative Control - CAS 852547-30-9 - Calbiochem

The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one

Primary Target: A negative control for PKR Inhibitor
527455
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
852547-30-9C₁₅H₈Cl₃NO₂

Products

Número de referenciaEmbalaje Cant./Env.
527455-10MG Frasco de vidrio 10 mg
Description
OverviewAn oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC50 > 100 µM) or in rescuing PKR-dependent translation block.
Catalogue Number527455
Brand Family Calbiochem®
SynonymsRNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
References
ReferencesJammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
Product Information
CAS number852547-30-9
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₅H₈Cl₃NO₂
Chemical formulaC₁₅H₈Cl₃NO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA negative control for PKR Inhibitor
Purity≥95% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
527455-10MG 04055977270389

Documentation

PKR Inhibitor, Negative Control - CAS 852547-30-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

PKR Inhibitor, Negative Control - CAS 852547-30-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
527455

Referencias bibliográficas

Visión general referencias
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-September-2007 JSW
SynonymsRNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
DescriptionAn oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in the inhibition of RNA-induced PKR autophosphorylation (IC50 > 100 µM). Exhibits no ability to rescue the translational block imposed by human PKR.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number852547-30-9
Chemical formulaC₁₅H₈Cl₃NO₂
Structure formulaStructure formula
Purity≥95% by HPLC (sum of two isomers)
SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.