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14-788M PI3 Kinase (p110β/p85β) Murine, 250 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110β & untagged, recombinant, full length mouse p85β. For use in Kinase Assays.

14-788M
250 µg  Also available in 10 μg size (cat#14-788) and in bulk (cat# 14-788-K).
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-788M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPI3 Kinase (p110β/p85β) Murine, 250 µg
OverviewComplex of N-terminal 6His-tagged, recombinant, full-length mouse p110β and untagged, recombinant, full length mouse p85β.
References
Product Information
Quality LevelMQ300
Applications
ApplicationComplex of N-terminal 6His-tagged, recombinant, full-length mouse p110β & untagged, recombinant, full length mouse p85β. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceCoexpressed by baculovirus in Sf21 insect cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryPhosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM]
Gene Symbol
  • PIK3CB
  • DKFZp779K1237
  • PI3K
  • p110-BETA
  • PI3Kbeta
  • MGC133043
  • PIK3C1
Protein TargetPI3Kβ/p85β
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyPI3K/PI4K
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P42338 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1070 amino acids; 122762 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.
TISSUE SPECIFICITY: Expressed ubiquitously.
SIMILARITY: SwissProt: P42338 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Molecular Weightp110β MW = 125.5kDa, p85β MW = 81.4kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-788) and in bulk (cat# 14-788-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-788M 04053252509308

Documentation

Productos y aplicaciones relacionados

Alternative Packsize

Número de referencia Descripción
14-788 PI3 Kinase (p110β/p85β) Murine, 10 µg

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Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases