Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

14-792 PI 3-Kinase (p110α(H1047R)/p85α), 10 µg

Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.

PI 3-Kinase (p110α(H1047R)/p85α), 10 µg: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
14-792
10 µg  Also available in 250μg size --call for pricing and availability and reference catalog number 14-792M when ordering the 250μg size.
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-792
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPI 3-Kinase (p110α(H1047R)/p85α), 10 µg
OverviewComplex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R, and untagged, recombinant, human p85α full length.
Background InformationThe H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).
References
Product Information
Presentation50 mM Tris/HCl pH8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
Quality LevelMQ100
Applications
ApplicationComplex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.
Biological Information
SourceCo-expressed by baculovirus in Sf21 insect cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Gene Symbol
  • PIK3CA
  • PI3K
  • PK3CA
Protein TargetPI3Kα/p85α
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyPI3K/PI4K
UniProt Number
Molecular Weightp110α(H1047R) MW = 125 kDa, p85α MW = 84 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Packaging Information
Material Size10 µg
Material PackageAlso available in 250μg size --call for pricing and availability and reference catalog number 14-792M when ordering the 250μg size.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-792 04053252324574

Documentation

PI 3-Kinase (p110α(H1047R)/p85α), 10 µg Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

PI 3-Kinase (p110α(H1047R)/p85α), 10 µg Certificados de análisis

CargoNúmero de lote
PI 3-Kinase (p110#945;(H1047R)/p85#945;) - 1847258-A 1847258-A
PI 3-Kinase (p110α(H1047R)/p85α) - 2055149-A 2055149-A

Licencias necesarias e Información técnica

Cargo
Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

Ficha técnica

Cargo
PI 3-Kinase HTRF Assay

Productos y aplicaciones relacionados

Alternative Packsize

Número de referencia Descripción
14-792M PI 3-Kinase (p110α(H1047R)/p85α), 250 µg

Accessories

Número de referencia Descripción
14-783 PI3 Kinase (p110α(E545K)/p85α), 10 µg
14-785 PI3 Kinase (p110α/p85α) murine, 10 µg
14-786 PI3 Kinase (p110α/p65α) Murine, 10 µg
14-787 PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg
14-788 PI3 Kinase (p110β/p85β) Murine, 10 µg
14-790 PI3 Kinase (p110α/p65α), 10 µg
33-016 PI 3-Kinase HTRF™ Assay; 384 wells
33-017 PI 3-Kinase HTRF™ Assay; 1920 wells
14-558 PI3 Kinase (p120γ), 20 µg
14-602 PI3 Kinase (p110α/p85α) Protein, active, 20 µg
Show more

Familias de productos

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
Más información >>

Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases