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234490 PD 153035 - CAS 153436-54-5 - Calbiochem

An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; Ki = 6 pM).

PD 153035 - CAS 153436-54-5 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32

Primary Target: EGFR
234490
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
153436-54-5C₁₆H₁₄BrN₃O₂

Products

Número de referenciaEmbalaje Cant./Env.
234490-1MG Ampolla de plást. 1 mg
Description
OverviewAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
Catalogue Number234490
Brand Family Calbiochem®
SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
References
ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
Fry, D.W., et al. 1994. Science 265, 1093.
Product Information
CAS number153436-54-5
ATP CompetitiveY
DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
FormWhite solid
Hill FormulaC₁₆H₁₄BrN₃O₂
Chemical formulaC₁₆H₁₄BrN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>25 pM
Primary Target K<sub>i</sub>6 pM against epidermal growth factor receptor (EGFR)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
234490-1MG 04055977200256

Documentation

PD 153035 - CAS 153436-54-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

PD 153035 - CAS 153436-54-5 - Calbiochem Certificados de análisis

CargoNúmero de lote
234490

Referencias bibliográficas

Visión general referencias
Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
Fry, D.W., et al. 1994. Science 265, 1093.

Folleto

Cargo
An Introduction to Inhibitors and Their Biological Applications - 1st Edition

Licencias necesarias e Información técnica

Cargo
JAK/STAT Signaling Research Focus

Póster

Cargo
Human Kinome & InhibitorSelect™ Libraries

Citas

Título
  • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.
    		•
    Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision05-April-2011 RFH
    SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
    DescriptionAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
    FormWhite solid
    CAS number153436-54-5
    Chemical formulaC₁₆H₁₄BrN₃O₂
    Structure formulaStructure formula
    Purity≥97% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
    Fry, D.W., et al. 1994. Science 265, 1093.
    Citation
  • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.
    		•