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528150 PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem

PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: PARP
528150
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
344458-15-7C₁₇H₁₇N₃O₂ · HCl

Products

Número de referenciaEmbalaje Cant./Env.
528150-1MG Ampolla de plást. 1 mg
528150-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).
Catalogue Number528150
Brand Family Calbiochem®
References
ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
Product Information
CAS number344458-15-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₁₇N₃O₂ · HCl
Chemical formulaC₁₇H₁₇N₃O₂ · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).
Biological Information
Primary TargetPARP
Primary Target IC<sub>50</sub>EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
528150-1MG 04055977196405
528150-5MG 04055977196412

Documentation

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem Certificados de análisis

CargoNúmero de lote
528150

Referencias bibliográficas

Visión general referencias
Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-January-2008 JSW
DescriptionA water-soluble phenanthridinone-derivative that acts as a potent anti-inflammatory agent and an inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number344458-15-7
Chemical formulaC₁₇H₁₇N₃O₂ · HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.