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14-699 PAK5 Protein, active, 10 µg

Active, N-terminal 6His-tagged, recombinant, human PAK5, amino acids 425-end. PAK5 is also known as PAK7. For use in Kinase Assays.

PAK5 Protein, active, 10 µg: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
14-699
10 µg  
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-699
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPAK5 Protein, active, 10 µg
OverviewN-terminal 6His-tagged, recombinant, human PAK5, amino acids 425-end. PAK5 is also known as PAK7.
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human PAK5, amino acids 425-end. PAK5 is also known as PAK7. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
Gene Symbol
  • PAK7
  • PAK-5
  • PAK5
  • MGC26232
  • KIAA1264
  • PAK-7
Protein TargetPAK5
Purification MethodNi2+/NTA-agarose
Target Sub-FamilySTE
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9P286 # The activated kinase acts on a variety of targets (By similarity).
SIZE: 719 amino acids; 80745 Da
SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity).
TISSUE SPECIFICITY: Predominantly expressed in brain.
PTM: Autophosphorylated when activated by CDC42/p21 (By similarity).
SIMILARITY: SwissProt: Q9P286 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
Molecular Weight37.4kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of PAKtide
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-699 04053252735691

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Alternative Packsize

Número de referencia Descripción
14-699M PAK5 Protein, active, 250 µg

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Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases