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495620 Olomoucine - CAS 101622-51-9 - Calbiochem

A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.

Olomoucine - CAS 101622-51-9 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Olomoucine

Primary Target: p34cdk1/cyclin B
495620
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
101622-51-9C₁₅H₁₈N₆O

Products

Número de referenciaEmbalaje Cant./Env.
495620-1MG Ampolla de plást. 1 mg
495620-5MG Ampolla de plást. 5 mg
Description
OverviewA purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µM) and related kinases including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44 MAP kinase (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 > 1 mM), and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495624) in DMSOis also available.
Catalogue Number495620
Brand Family Calbiochem®
SynonymsOlomoucine
References
ReferencesAbraham, R.T., et al. 1995. Biol. Cell 83, 105.
Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
Glab, N., et al. 1994. FEBS Lett. 353, 207.
Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.
Product Information
CAS number101622-51-9
ATP CompetitiveY
FormCrystalline solid
Hill FormulaC₁₅H₁₈N₆O
Chemical formulaC₁₅H₁₈N₆O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetp34cdk1/cyclin B
Primary Target IC<sub>50</sub>7 µM, 7 µM, 7 µM, 3 µM, 25 µM against p34cdk1/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, p33cdk5/p35, and p44 MAP kinase, respectively
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
495620-1MG 04055977199789
495620-5MG 04055977199796

Documentation

Olomoucine - CAS 101622-51-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Olomoucine - CAS 101622-51-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
495620

Referencias bibliográficas

Visión general referencias
Abraham, R.T., et al. 1995. Biol. Cell 83, 105.
Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
Glab, N., et al. 1994. FEBS Lett. 353, 207.
Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2018 JSW
SynonymsOlomoucine
DescriptionA purine derivative that acts as a potent, reversible, and selective inhibitor of p34cdc2/cyclin B (IC50 = 7 µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44MAPK (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 > 1000 µM) and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases even at 1 mM concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.
FormCrystalline solid
CAS number101622-51-9
Chemical formulaC₁₅H₁₈N₆O
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAbraham, R.T., et al. 1995. Biol. Cell 83, 105.
Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
Glab, N., et al. 1994. FEBS Lett. 353, 207.
Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.