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482210 Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem

A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against SKBR-3, BT474 and MDA-MB-453, and affects MCF-7 and MDA-MB-231 only at much higher concentrations.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide

482210
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
1021926-22-6C₂₄H₃₂N₂O₄S

Products

Número de referenciaEmbalaje Cant./Env.
482210-5MG 5 mg
Description
OverviewA cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.
Catalogue Number482210
Brand Family Calbiochem®
SynonymsN-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide
References
ReferencesChen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
Su, B., et al. 2008. J. Comb. Chem. 10, 475.
Product Information
CAS number1021926-22-6
FormOff-white solid
Hill FormulaC₂₄H₃₂N₂O₄S
Chemical formulaC₂₄H₃₂N₂O₄S
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
482210-5MG 04055977183504

Documentation

Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem Certificados de análisis

CargoNúmero de lote
482210

Referencias bibliográficas

Visión general referencias
Chen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
Su, B., et al. 2008. J. Comb. Chem. 10, 475.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
SynonymsN-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide
DescriptionA cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.
FormOff-white solid
CAS number1021926-22-6
Chemical formulaC₂₄H₃₂N₂O₄S
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesChen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
Su, B., et al. 2008. J. Comb. Chem. 10, 475.