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399250 NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: NOHA, AcOH

Primary Target: liver and macrophage arginase
399250
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
53598-01-9C₆H₁₄N₄O₃ · CH₃CO₂H

Products

Número de referenciaEmbalaje Cant./Env.
399250-5MG Ampolla de plást. 5 mg
Description
OverviewCell permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).
Catalogue Number399250
Brand Family Calbiochem®
SynonymsNOHA, AcOH
References
ReferencesBoucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963.
Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880.
Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259.
Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528.
Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.
Product Information
CAS number53598-01-9
FormWhite solid
Hill FormulaC₆H₁₄N₄O₃ · CH₃CO₂H
Chemical formulaC₆H₁₄N₄O₃ · CH₃CO₂H
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetliver and macrophage arginase
Primary Target K<sub>i</sub>150 µM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
399250-5MG 04055977212556

Documentation

NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
399250

Referencias bibliográficas

Visión general referencias
Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963.
Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880.
Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259.
Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528.
Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.

Folleto

Cargo
Pathways and Biomarkers of Oxidative Stress
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2023 JSW
SynonymsNOHA, AcOH
DescriptionCell-permeable. A key intermediate product in the biosynthesis of nitric oxide from arginine by constitutive nitric oxide synthase (cNOS). Formed by the NADPH-dependent hydroxylation of L-arginine. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450, providing an alternative biosynthetic route for the production of nitric oxide. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number53598-01-9
Chemical formulaC₆H₁₄N₄O₃ · CH₃CO₂H
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBoucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963.
Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880.
Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259.
Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528.
Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.