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504908 Myeloperoxidase Inhibitor-II - CAS 1256348-67-0 - Calbiochem

504908
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Descripción

Tabla espec. clave

CAS #Empirical Formula
1256348-67-0C₁₂H₁₃FN₂O

Products

Número de referenciaEmbalaje Cant./Env.
5049080001 Frasco de vidrio 10 mg
Description
OverviewA 5-fluorotryptamine derivative that inhibits myeloperoxidase/MPO activity (IC50 = 18 nM) via direct affinity interaction with enzyme active site heme pyrrole ring D, while exhibiting much reduced affinity toward serotonin reuptake transporter/SERT (Ki = 631 nM). Kinetic studies reveal that the inhibitor acts as a good one-electron donor for the intermediate Compound I "Fe(IV)=O...Por•+", facilitating the formation of Compound II (Fe(IV)-OH...Por) and thereby preventing the reduction of Compound I directly to the resting state "Fe(IV)...Por" via the "halogenation cycle", while, on the other hand, behaves as a poor electron donor for Compound II, thereby preventing the completion of the "peroxidase cycle" by stalling the further reduction of Compound II to the resting state.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number504908
Brand Family Calbiochem®
Synonyms4-(5-Fluoro-1H-indol-3-yl)butanamide, MPO Inhibitor II
References
ReferencesSoubhye, J., et al. 2013. J. Med. Chem. 56, 3943.
Soubhye, J., et al. 2010. J. Med. Chem. 53, 8747.
Product Information
CAS number1256348-67-0
FormLight beige powder
Hill FormulaC₁₂H₁₃FN₂O
Chemical formulaC₁₂H₁₃FN₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetmyeloperoxidase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Número de referencia GTIN
5049080001 04055977263664