Mobius® FlexReady Solution for Large Scale Clarification
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| Biopharmaceutical Manufacturing > Downstream Processing > Single-use Manufacturing > Mobius Mixing Systems |
Mobius® FlexReady Solution for Large Scale Clarification provides the best combination of Flexware® single-use assemblies, innovative separation devices, and process-ready hardware systems that deliver optimal operational flexibility, from clinical production to full-scale commercial manufacturing.
- Fast setup of hardware with easy installation of optimally designed Flexware® assemblies
- Maximum adaptability to your changing operational needs with single-use flowpaths
- Self-contained and single-use, eliminating maintenance and cleaning validation requirements
Clarification Featuring Millistak+® Pod Disposable Depth Filter System
The Mobius® FlexReady Solution for Large Scale Clarification is ideally suited for primary and secondary clarification of high cell density, low viability mammalian cell culture using Millistak+® Pod disposable depth filters, and is capable of processing up to 5kg of protein or 2000 L volumes at 2.5 g/L expression.
Benefits
- Low pulsation single-use pump chamber
- Constant speed operation
- High-pressure cut off switch ensures operator safety
- Innovative low dead volume t-connectors – enabling the use of traditional pressure transducers
- Single-use adapters – connect Millistak+® Pods to process piping, creating a disposable flow path
- Single-use diverter plates – enable more than one media grade on a single rack
| Large Scale FlexReady Solution | |
| Overall Dimensions (H x W x D) mm: | 1 rack + 1 pump: 1158 x 2343 x 770 2 racks + 2 pumps: 1558 x 2543 x 770 3 racks + 3 pumps: 1605 x 2743 x 770 4 racks + 3 pumps: 1605 x 2743 x 1640 |
| Materials of Construction | |
| Diverter plate: | Polypropylene |
| End plates: | 304 stainless steel |
| End plate clamp and guide rods | 17–4 PH steel |
| All other metal surfaces | All other metal surfaces |
| TC gaskets | Thermoplastic Elastomer (TPE) |
| TC clamp | 304 stainless steel 2 piece clamp |
| Performance Properties | |
| Capable of supporting and sealing Millistak+® Pod filters up to 50 psig maximum operating pressure at 25 °C. Inlet and outlet connection to the Millistak+® Pods and vents are via disposable adapters. |
|
| Maximum differential pressure for Millistak+® Pod device | |
| Forward: | 3.5 bar (50 psid) at 25 °C; 1.0 bar (15 psid) at 80 °C |
| Reverse: | 2.1 bar (30 psid) at 25 °C |
| Total Weight | 500 to 1500 kg |
| Wheels | |
| No. Total: | From 8 to 12 |
| No. Locking: | From 4 to 6 |
| Utility Requirements: | |
| 240 Vac countries | |
| 1 pump | 1 x 230 Vac, + N, + G, 50/60 Hz Power consumption: 1.4 kW |
| 2 pumps | 1 x 230 Vac, + N, + G, 50/60 Hz Power consumption: 2.1 kW |
| 3 pumps | 1 x 230 Vac, + N, + G, 50/60 Hz Power consumption: 2.8 kW |
| 110 Vac countries | |
| 1 pump | 1 x 110 Vac, + N, + G, 50/60 Hz Power consumption: 1 kW |
| 2 pumps | 1 x 110 Vac, + N, + G, 50/60 Hz Power consumption: 1.6 kW |
| 3 pumps | 3 x 110 Vac, + G, 50/60 Hz Power consumption: 2.2 kW |
| Electrical Enclosure: | IP 65 (NEMA 4X) |
| Electrical Compliance: | CE (2004/108/CE, 2006/42/CE), UL 508 A |
| Environmental Temperature Range: | 4-25°C |
| Humidity: | 10 – 90% (non condensing) |
| Pressure Rating: | up to 2.1 bar (30 psig) |
| Process Fluid Temperature Range: | 4-30°C |
| Process Connection Type: | TC connectors |
| Materials of Construction | |
| Tubing: | Different grade of silicone, polypropylene, Nylon, EPDM, Santoprene® resin |
| Frame: | Stainless steel 304 (some parts are painted) |
| Regulatory Information: | Sealing materials and plastics in contact with the product meet USP biological reactivity test for Class VI Plastics and are Title 21 CFR 177.2600 and 177.1550 compliant. |
| Tubing Sizes: | 5/8" ID up to 20 LPM 3/4” ID up to 40 LPM 1” ID up to 60 LPM |
| Inlets: | Up to 3 inlets on manifold (TC) |
| Outlets: | Up to 2 drain lines (TC) + 1 collection (TC) |
| Membrane Holder Capacity | |
| Primary grade: | From 1.1 to 33 m² |
| Recommended grade aspect ratio | 1:3 |
| Available flux (LMH) w/ 11m² | 109 to 327 L/h/m² |
| Available flux (LMH) w/ 22m² | 109 to 163 L/h/m² |
| Available flux (LMH) w/ 33m² | Up to 109 L/h/m² |
| Pumps | |
| Brand: | Quattroflow™/Almatech |
| Model: | 1200S |
| Number: | 1 to 3 |
| Flow range: | 2 to 60 LPM |
| Valves | |
| Type: | Manual |
| Brand: | Pinch Valve Biovalve 1/2 -1 |
| Model: | 1/2-1 |
| Pressure Switch | |
| Type: | Non intrusive |
| Location: | After pumps |
| Brand: | Labom |
| Model: | Pascal CV 3110 |
| Range: | 0 - 6 bar |
| Loop accuracy: | ± 0.2 bar |
| Sensors | |
| Pressure (Optional): | |
| Type : | Gauge (or transmitter if recorder option), non intrusive |
| Location: | Before recovery |
| Brand: | Labom |
| Model: | Type Series BH52 or CC60 |
| Range: | 0 - 6 bar |
| Loop accuracy: | ± 0.2 bar |
| Pressure (Optional): | |
| Type: | Gauge (or transmitter if recorder option), non intrusive |
| Location: | Between both grades |
| Brand: | Labom |
| Model: | Type Series BH52 or CC60 |
| Range: | 0 - 6 bar |
| Loop accuracy: | ± 0.2 bar |
| Weight scale (Optional): | |
| Location: | Filtrate line for recovery bag |
| Brand: | Metler Toledo |
| Model: | PFA579-FM3000 |
| Range: | 0-3000 kg |
| Loop accuracy: | ± 0.1% FS |
| Control Loops: | N/A |
| Automation: | Fully manual system Recorder as an option (analog values) |
| Documentation: | User Manual: 1 paper copy + on CD Technical Documentation: on CD QA documentation: on CD |