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FCMAB257P Milli-Mark™Anti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5

Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5 detects level of Glial Fibrillary Acidic Protein & has been published & validated for use in FC.

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Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: GFAP, FLJ45472 UniProt Number: P14136
FCMAB257P
100 tests  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMPhycoerythrinMonoclonal Antibody
Description
Catalogue NumberFCMAB257P
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™Anti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5
Alternate Names
  • GFAP
Background InformationGlial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
Product Information
FormatPhycoerythrin
Control
  • U251 cells
PresentationPurified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationMilli-MarkAnti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5 detects level of Glial Fibrillary Acidic Protein & has been published & validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenPurified glial filament (Debus, E., 1983).
CloneGA5
HostMouse
SpecificityAntibody recognizes Human Glial Fibrillary Acidic Protein.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined
Gene Symbol
  • GFAP
  • FLJ45472
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

SIZE: 432 amino acids; 49880 Da

SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.

SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.

DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.

SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family. ...
Molecular Weight50 kDa Calculated
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using U251 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Global Trade Item Number
Número de referencia GTIN
FCMAB257P 04053252413179