Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

FCMAB404PE Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33

Milli-Mark Anti-Tie2/TEK-PE Antibody, clone Ab33 is an antibody against Tie2/TEK for use in FC.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: TEK, TIE2 UniProt Number: Q02763
FCMAB404PE
100 tests  
Purchase on Sigma-Aldrich

Ofertas especiales

Descripción

Replacement Information

Ofertas especiales

100% Performance Guaranteed

Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMPhycoerythrinMonoclonal Antibody
Description
Catalogue NumberFCMAB404PE
Trade Name
  • Milli-Mark
DescriptionMilli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33
Alternate Names
  • Tunica interna endothelial cell kinase
  • Tyrosine-protein kinase receptor TEK
  • Tyrosine-protein kinase receptor TIE-2
  • hTIE2
  • p140 TEK
  • CD202b
Background InformationTIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin-like loops separated by three epidermal growth factor-like repeats that are connected to three fibronectin type III-like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.
References
Product Information
FormatPhycoerythrin
Control
  • HUVEC cells
PresentationPurified mouse monoclonal IgG1k conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationMilli-Mark Anti-Tie2/TEK-PE Antibody, clone Ab33 is an antibody against Tie2/TEK for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenFusion protein corresponding to residues 1-745 of human Tie2/TEK with a C-terminal His6-tag purified from infected SF-9 cells.
CloneAb33
HostMouse
SpecificityAntibody recognizes Human Tie2/TEK.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Gene Symbol
  • TEK
  • TIE2
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q02763 # This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.

SIZE: 1124 amino acids; 125811 Da

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

TISSUE SPECIFICITY: Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.

DISEASE:SwissProt: Q02763 # Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated, serpiginous channels.

SIMILARITY: SwissProt: Q02763 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. & Contains 3 EGF-like domains. & Contains 3 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Molecular Weight126 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using HUVEC cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
FCMAB404PE 04053252294631

Documentation

Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33 Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33 Certificados de análisis

CargoNúmero de lote
Milli-Mark#174; Anti-Tie2/TEK-PE, clone Ab33 - 2110535 2110535
Milli-Mark#174; Anti-Tie2/TEK-PE, clone Ab33 - 2161159 2161159
Milli-Mark#174; Anti-Tie2/TEK-PE, clone Ab33 - 2074063 2074063
Milli-Mark#174; Anti-Tie2/TEK-PE, clone Ab33 - 2104034 2104034
Milli-Mark#174; Anti-Tie2/TEK-PE, clone Ab33 - 2106929 2106929
Milli-Mark#174; Anti-Tie2/TEK-PE, clone Ab33 - Q1980184 Q1980184
Milli-Mark™ Anti-Tie2/TEK-PE, -2615072 2615072
Milli-Mark™ Anti-Tie2/TEK-PE, -2686137 2686137
Milli-Mark™ Anti-Tie2/TEK-PE, -2779748 2779748
Milli-Mark™ Anti-Tie2/TEK-PE, clone Ab33 2478035
Show more

Productos y aplicaciones relacionados

Related Products

Número de referencia Descripción
05-584 Anti-Tie2/TEK Antibody, clone Ab33
07-1431 Anti-Tie-2 Antibody, NT
ABF131 Anti-phospho TIE2/TEK Antibody (Tyr992)
ABS219 Anti-phospho-Tie2 (Ser1119) Antibody

Familias de productos

Endothelial Cell Markers

The thin layer of cells that lines the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
Más información >>

Productos relacionados por: Brand Facete

Milli-Mark™

Categorías

Life Science Research > Antibodies and Assays > Primary Antibodies