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474700 Mevastatin - CAS 73573-88-3 - Calbiochem

An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation.

Mevastatin - CAS 73573-88-3 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Compactin

Primary Target: HMG-CoA reductase
474700
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
73573-88-3C₂₃H₃₄O₅

Products

Número de referenciaEmbalaje Cant./Env.
474700-50MG Ampolla de plást. 50 mg
Description
OverviewAn antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation. Inhibitor of myoblast fusion. Also may induce bone morphogenic protein-2 (BMP-2). Causes cell cycle arrest in late G1 phase.
This is an inactive form which may require activation for use with isolated cells depending upon the application. To activate, treat with NaOH in ethanol and then neutralize to pH 7.2.
Catalogue Number474700
Brand Family Calbiochem®
SynonymsCompactin
References
ReferencesSugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.
Product Information
CAS number73573-88-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₃₄O₅
Chemical formulaC₂₃H₃₄O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHMG-CoA reductase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEK7907100
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
474700-50MG 07790788050429

Documentation

Mevastatin - CAS 73573-88-3 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Mevastatin - CAS 73573-88-3 - Calbiochem Certificados de análisis

CargoNúmero de lote
474700

Referencias bibliográficas

Visión general referencias
Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2008 RFH
SynonymsCompactin
DescriptionAn antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppresses Ras farnesylation. Inhibitor of myoblast fusion. Causes cell cycle arrest in late G1 phase. May induce bone morphogenic protein-2 (BMP-2). This product requires activation for use in cell culture and cell-free assay systems. To activate, treat with ethanol solution with 1 N NaOH and then neutralize with 1 N HCl to pH 7.2 (see Keyomarsi, K . et al. 1991).
FormWhite solid
CAS number73573-88-3
RTECSEK7907100
Chemical formulaC₂₃H₃₄O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityEthanol
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 6164
ReferencesSugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.