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444130 Mcl-1 Inhibitor, MIM1 - Calbiochem

Mcl-1 Inhibitor, MIM1 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1

444130
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Descripción

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Número de referenciaEmbalaje Cant./Env.
444130-25MG Frasco de vidrio 25 mg
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Description
OverviewA cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/-Bak-/- MEF.
Catalogue Number444130
Brand Family Calbiochem®
Synonyms4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1
References
ReferencesCohen, N.A., et al. 2012. Chem. Biol. 19, 1175.
Product Information
FormYellow powder
Hill FormulaC₁₇H₂₁N₃O₃S
Chemical formulaC₁₇H₂₁N₃O₃S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMcl-1
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Número de referencia GTIN
444130-25MG 04055977205428