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444250 MMP Inhibitor I - Calbiochem

MMP Inhibitor I, CAS 124168-73-6, is an inhibitor of multiple MMPs (IC50 = 1.0, 1.0, 150, and 30 M for MMP-1, MMP-8, MMP-3, and MMP-9, respectively).

MMP Inhibitor I - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: FN-439

Primary Target: MMP-1, MMP-8
444250
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₃H₃₄N₆O₆

Products

Número de referenciaEmbalaje Cant./Env.
444250-10MG Ampolla de plást. 10 mg
Description
OverviewA tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC50 = 1.0 µM), MMP-9 (IC50 = 30 µM) and MMP-3 (IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE® Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase.
Catalogue Number444250
Brand Family Calbiochem®
SynonymsFN-439
References
ReferencesHagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₃₄N₆O₆
Chemical formulaC₂₃H₃₄N₆O₆
ReversibleN
Quality LevelMQ100
Applications
ApplicationMMP Inhibitor I, CAS 124168-73-6, is an inhibitor of multiple MMPs (IC50 = 1.0, 1.0, 150, and 30 M for MMP-1, MMP-8, MMP-3, and MMP-9, respectively).
Biological Information
Primary TargetMMP-1, MMP-8
Primary Target IC<sub>50</sub>1 µM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide Sequence4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
444250-10MG 04055977186505

Documentation

MMP Inhibitor I - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

MMP Inhibitor I - Calbiochem Certificados de análisis

CargoNúmero de lote
444250

Referencias bibliográficas

Visión general referencias
Hagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

Citas

Título
  • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
    		•
    Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision23-October-2024 JSW
    SynonymsFN-439
    DescriptionA tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE® Protease (Cat. No. 53702) or human neutrophil elastase.
    FormWhite solid
    Chemical formulaC₂₃H₃₄N₆O₆
    Peptide Sequence4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
    Purity≥95% by HPLC
    SolubilityH₂O (1 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Standard Handling
    ReferencesHagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
    Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
    Citation
  • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
    		•