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444937 MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv

The MEK Inhibitor I, also referenced under CAS 297744-42-4, controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: MEK
444937
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
297744-42-4C₂₁H₁₈N₄OS

Products

Número de referenciaEmbalaje Cant./Env.
444937-1MG Ampolla de plást. 1 mg
Description
OverviewA cell-permeable pyridine-containing vinylogous cyanamide compound that acts as a potent and selective inhibitor of MEK (IC50 = 12 nM) with little activity towards MKK3 and MKK4 (IC50 > 1 µM). The inhibition is noncompetitive with respect to ERK and the compound displays significant affinity only towards ATP-bound MEK (i.e. noncompetitive with respect to ATP). Exhibits superior potency, solubility, and stability compared to U0126 (Cat. No. 662005) in aqueous solutions. Shown to protect against phorbol ester-mediated ear edema in mice (ED50 of 5 mg/kg, ip.).
Catalogue Number444937
Brand Family Calbiochem®
References
ReferencesWityak, J., et al. 2004. Bioorg. Med. Chem. Lett. 14, 1483.
Product Information
CAS number297744-42-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₁H₁₈N₄OS
Chemical formulaC₂₁H₁₈N₄OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMEK
Primary Target IC<sub>50</sub>12 nM against MEK
Purity≥ 95% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
444937-1MG 04055977186215

Documentation

MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv Certificados de análisis

CargoNúmero de lote
444937

Referencias bibliográficas

Visión general referencias
Wityak, J., et al. 2004. Bioorg. Med. Chem. Lett. 14, 1483.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
DescriptionA cell-permeable, potent, and selective inhibitor of MEK (IC50 = 12 nM) with little activity towards MKK3 and MKK4 (IC50 >1 µM). The inhibition is non-competitive with respect to ERK and the compound displays significant affinity only towards ATP-bound MEK (i.e. non-competitive with respect to ATP). Exhibits superior potency, solubility, and stability compared to U0126 (Cat. No. 662005) in aqueous solutions. Shown to protect against phorbol ester-mediated ear edema in mice (ED50 of 5 mg/kg, ip.).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number297744-42-4
Chemical formulaC₂₁H₁₈N₄OS
Structure formulaStructure formula
Purity≥ 95% by HPLC (sum of two isomers)
SolubilityDMSO (10 mg/ml) or Methanol (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWityak, J., et al. 2004. Bioorg. Med. Chem. Lett. 14, 1483.