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LPI-16K LisPro Insulin RIA

This radioimmunoassay (RIA) measures & quantifies Insulin for use in Metabolism & Endocrine research.

LisPro Insulin RIA: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Key Applications: Radioimmunoassay Detection Methods: Radioactive, 125I Research Category: Metabolism Research Sub-Category: Obesity, Metabolic Disorders
LPI-16K
250 tubes  
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
Insulin HRIARadioactive 125I
Description
Catalogue NumberLPI-16K
DescriptionLisPro Insulin RIA
Background InformationLispro insulin (Humalog®) is a synthetic human insulin analog showing drastic reductions of inter-molecular aggregations. It has a higher rate of absorption, higher peak serum levels and a shorter duration of action than regular human insulin following s
References
Product Information
Detection methodRadioactive 125I
Performance
  • ED80 = 10 ± 1 µU/ml
  • ED50 = 36 ± 2 µU/ml
  • ED20 = 136 ± 5 µU/ml
Quality LevelMQ100
Applications
ApplicationThis radioimmunoassay (RIA) measures & quantifies Insulin for use in Metabolism & Endocrine research.
Key Applications
  • Radioimmunoassay
Application NotesOvernight assay Equilibrium incubation at room tempature. Sample volume 100 µL serum, plasma, or tissue culture media
Biological Information
SpecificityLis/Pro Insulin 100% Human Insulin <0.05% Human Proinsulin <0.05% Bovine Proinsulin Not Detectable Porcine Proinsulin Not Detectable
Species Reactivity
  • Human
Analytes Available
  • Insulin
Entrez Gene Number
Entrez Gene SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
Gene Symbol
  • INS
  • proinsulin
  • insulin
Radioactive Isotype125I-LisPro Insulin
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SIZE: 110 amino acids; 11981 Da
SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
Physicochemical Information
Sensitivity
  • sVCAM-1 33.0
  • sICAM-1 30.0
  • sFas 7.0
  • sFasL 6.0
  • MIF 10.0
  • PAI-1 3.2
Standard Curve Range
  • 2.5–250 µU/mL
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size250 tubes
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
LPI-16K 04053252624018

Documentation

Protocols

Title
Protocol: LISPRO INSULIN RIA KIT

LisPro Insulin RIA Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referenciasPub Med ID
A novel insulin formulation with a more rapid onset of action.
S Steiner,M Hompesch,R Pohl,P Simms,F Flacke,T Mohr,A Pfützner,L Heinemann
Diabetologia  51  2008

Mostrar resumen Artículo Texto completo		18641968 18641968

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