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14-919M LRRK2 Protein, active, 250 µg

Active, N-terminal FLAG-tagged, recombinant, human LRRK2, amino acids 970-end. For use in Kinase Assays.

LRRK2 Protein, active, 250 µg: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
14-919M
250 µg  Also available in 10μg size as catalog # 14-919 and in bulk as catalog # 14-919-K.
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-919M
Trade Name
  • Upstate
DescriptionLRRK2 Protein, active, 250 µg
OverviewThis protein is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
References
Product Information
Presentation50mM Tris/HCl pH7.4, 300mM NaCl, 20mM β-glycerophosphate, 0.25mM sodium orthovanadate, 10mM NaF, 150µg/ml FLAG peptide, 20% v/v glycerol, 1mM benzamidine, 0.2mM PMSF, 5mM DTT. Frozen solution.
Quality LevelMQ300
Applications
ApplicationActive, N-terminal FLAG-tagged, recombinant, human LRRK2, amino acids 970-end. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceN-terminal FLAG-tagged, recombinant, human LRRK2 amino acids 970-end, expressed by baculovirus in Sf21 insect cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Gene Symbol
  • LRRK2
  • PARK8
  • RIPK7
  • ROCO2
  • AURA17
  • DARDARIN
Purification MethodImmunoaffinity Chromatography
Target Sub-FamilyTKL
UniProt Number
Molecular Weight180 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of ERMtide (RLGRDKYKTLRQIRQ)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10μg size as catalog # 14-919 and in bulk as catalog # 14-919-K.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-919M 04053252825484

Productos y aplicaciones relacionados

Alternative Packsize

Número de referencia Descripción
14-919 LRRK2 Protein, active, 10 µg

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Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases