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14-686M LOK Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant human LOK amino acids 1-348, for use in Kinase Assays.

14-686M
250 µg  Also available in 10 μg size (cat#14-686) and in bulk (cat#14-686-K).
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-686M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionLOK Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant human LOK amino acids 1-348
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant human LOK amino acids 1-348, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
Gene Symbol
  • STK10
  • PRO2729
  • LOK
Protein TargetLOK
Purification MethodNi2+/NTA-agarose
Target Sub-FamilySTE
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O94804 # Can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues (By similarity).
SIZE: 968 amino acids; 112135 Da
TISSUE SPECIFICITY: Expressed predominantly in lymphoid organs.
PTM: Autophosphorylated (By similarity).
SIMILARITY: SwissProt: O94804 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain.
Molecular Weight43.2kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of Axltide (Catalog# 12-516)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditionsstable 6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-686) and in bulk (cat#14-686-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-686M 04053252925177

Documentation

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Alternative Packsize

Número de referencia Descripción
14-686 LOK Protein, active, 10 µg

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Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases