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508228 L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: gamma-glutamylcysteine synthetase
508228
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
83730-53-4C₈H₁₈N₂O₃S

Products

Número de referenciaEmbalaje Cant./Env.
5082280001 Frasco de vidrio 100 mg
Description
OverviewA cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
Catalogue Number508228
Brand Family Calbiochem®
References
ReferencesFruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.
Product Information
CAS number83730-53-4
FormWhite powder
Hill FormulaC₈H₁₈N₂O₃S
Chemical formulaC₈H₁₈N₂O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetgamma-glutamylcysteine synthetase
Purity≥97% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
5082280001 04055977261790

Documentation

L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referencias
Fruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2013 JSW
DescriptionA cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number83730-53-4
Chemical formulaC₈H₁₈N₂O₃S
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityH₂O (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.