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422708 KN-93 - CAS 139298-40-1 - Calbiochem

KN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.

KN-93 - CAS 139298-40-1 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)

Primary Target: cam kinase 2
422708
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
139298-40-1C₂₆H₂₉CIN₂O₄S

Products

Número de referenciaEmbalaje Cant./Env.
422708-1MG Ampolla de plást. 1 mg
422708-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki = 370 nM). Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effects on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH/3T3 cells. A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422712) in DMSO is also available.
Catalogue Number422708
Brand Family Calbiochem®
Synonyms2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
References
ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
Product Information
CAS number139298-40-1
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₆H₂₉CIN₂O₄S
Chemical formulaC₂₆H₂₉CIN₂O₄S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationKN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.
Biological Information
Primary Targetcam kinase 2
Primary Target K<sub>i</sub>370 nM against rat brain CaM kinase II
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
422708-1MG 04055977187243
422708-5MG 04055977187250

Documentation

KN-93 - CAS 139298-40-1 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

KN-93 - CAS 139298-40-1 - Calbiochem Certificados de análisis

CargoNúmero de lote
422708

Referencias bibliográficas

Visión general referencias
Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-November-2009 RFH
Synonyms2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
DescriptionCell-permeable, reversible, and competitive inhibitor of rat brain Ca+2/calmodulin-dependent protein kinase II (Ki = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
FormOff-white solid
CAS number139298-40-1
Chemical formulaC₂₆H₂₉CIN₂O₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Irritant
ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.