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420360 KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem

The KMO Inhibitor I, Ro 61-8048, also referenced under CAS 199666-03-0, controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide

420360
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
199666-03-0C₁₇H₁₅N₃O₆S₂

Products

Número de referenciaEmbalaje Cant./Env.
420360-10MG Frasco de vidrio 10 mg
Description
OverviewA cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki = 4.8 nM; IC50 = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361).
Catalogue Number420360
Brand Family Calbiochem®
SynonymsKynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide
References
ReferencesCampesan, S., et al. 2011. Chem. Biol. 21, 961.
Zwilling, D., et al. 2011. Cell 145, 863.
Giorgini, F., et al. 2005. Nat. Genet. 37, 526.
Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab. 19, 771,
Rover, S., et al. 1997. J. Med. Chem. 40, 4378.
Product Information
CAS number199666-03-0
FormYellow solid
Hill FormulaC₁₇H₁₅N₃O₆S₂
Chemical formulaC₁₇H₁₅N₃O₆S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
420360-10MG 04055977187557

Documentation

KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem Certificados de análisis

CargoNúmero de lote
420360

Referencias bibliográficas

Visión general referencias
Campesan, S., et al. 2011. Chem. Biol. 21, 961.
Zwilling, D., et al. 2011. Cell 145, 863.
Giorgini, F., et al. 2005. Nat. Genet. 37, 526.
Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab. 19, 771,
Rover, S., et al. 1997. J. Med. Chem. 40, 4378.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-August-2012 JSW
SynonymsKynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide
DescriptionA cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki = 4.8 nM; IC50 = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number199666-03-0
Chemical formulaC₁₇H₁₅N₃O₆S₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (12.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCampesan, S., et al. 2011. Chem. Biol. 21, 961.
Zwilling, D., et al. 2011. Cell 145, 863.
Giorgini, F., et al. 2005. Nat. Genet. 37, 526.
Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab. 19, 771,
Rover, S., et al. 1997. J. Med. Chem. 40, 4378.