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407601 Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

407601
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
509093-47-4C₂₀H₂₁N₅O₄

Products

Número de referenciaEmbalaje Cant./Env.
407601-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).
Catalogue Number407601
Brand Family Calbiochem®
SynonymsIRAK-1/4 Inhibitor, N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole
References
ReferencesBhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
Product Information
CAS number509093-47-4
ATP CompetitiveN
FormYellow crystalline solid
Hill FormulaC₂₀H₂₁N₅O₄
Chemical formulaC₂₀H₂₁N₅O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInterleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, CAS 509093-47-4, is a cell-permeable, potent and selective inhibitor of IRAK-1 (IC50 = 300 nM) and IRAK-4 (IC50 = 200 nM).
Biological Information
Primary TargetInterleukin-1 receptor-associated kinases
Primary Target IC<sub>50</sub>300 nM and 200 nM for IRAK-1 and -4
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
407601-5MG 04055977211290

Documentation

Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem Certificados de análisis

CargoNúmero de lote
407601

Referencias bibliográficas

Visión general referencias
Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.

Folleto

Cargo
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-November-2012 JSW
SynonymsIRAK-1/4 Inhibitor, N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole
DescriptionA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src.
FormYellow crystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number509093-47-4
Chemical formulaC₂₀H₂₁N₅O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesBhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.