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407325 Interferon-α-IFNα-R Interaction Inhibitor - Calbiochem

The Interferon-α-IFNα-R Interaction Inhibitor controls the biological activity of Interferon-α-IFNα-R.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, IFN-α Inhibitor

407325
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₈H₁₇NS •HCl

Products

Número de referenciaEmbalaje Cant./Env.
407325-25MG Frasco de vidrio 25 mg
Description
OverviewA nonpeptidic thiophenylmethanamine compound that binds interferon-α (Kd = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC50 <4.5 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).
Catalogue Number407325
Brand Family Calbiochem®
SynonymsN-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, IFN-α Inhibitor
References
ReferencesGeppert, T., et al. 2011. Angew. Chem. Int. Ed. 51, 258.
Product Information
FormWhite solid
Hill FormulaC₁₈H₁₇NS •HCl
Chemical formulaC₁₈H₁₇NS •HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
407325-25MG 04055977188349

Documentation

Interferon-α-IFNα-R Interaction Inhibitor - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Interferon-α-IFNα-R Interaction Inhibitor - Calbiochem Certificados de análisis

CargoNúmero de lote
407325

Referencias bibliográficas

Visión general referencias
Geppert, T., et al. 2011. Angew. Chem. Int. Ed. 51, 258.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-September-2012 JSW
SynonymsN-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, IFN-α Inhibitor
DescriptionA nonpeptidic thiophenylmethanamine compound that binds interferon-α (Kd = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA (vaccinia virus Ankara) infection (IC50 <4.5 µM), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95% inhibition at 9 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₇NS •HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml; clear, colorless solution)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGeppert, T., et al. 2011. Angew. Chem. Int. Ed. 51, 258.