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407241 Insulin Degrading Enzyme, His•Tag®, Rat, Recombinant, S. frugiperda

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Insulysin, IDE

407241
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Products

Número de referenciaEmbalaje Cant./Env.
407241-50UG Ampolla de plást. 50 μg
Description
OverviewRecombinant, rat insulin degrading enzyme fused to a His•Tag® sequence and expressed in S. frugiperda insect cells. A metalloprotease that degrades insulin and a variety of other peptides including amyloid peptides.
Catalogue Number407241
Brand Family Calbiochem®
SynonymsInsulysin, IDE
References
ReferencesHersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.
Product Information
Unit of DefinitionOne unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.
EC number3.4.24.56
FormLiquid
FormulationIn 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by SDS-PAGE
Specific Activity≥3 U/mg protein
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
407241-50UG 04055977188646

Documentation

Insulin Degrading Enzyme, His•Tag®, Rat, Recombinant, S. frugiperda Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Insulin Degrading Enzyme, His•Tag®, Rat, Recombinant, S. frugiperda Certificados de análisis

CargoNúmero de lote
407241

Referencias bibliográficas

Visión general referencias
Hersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-March-2008 JSW
SynonymsInsulysin, IDE
DescriptionRecombinant, rat insulin degrading enzyme fused to a His•Tag® sequence and expressed in S. frugiperda insect cells. Insulin degrading enzyme (Insulysin) is a metalloprotease that degrades insulin and a variety of other peptides, including glucagon, insulin-like growth factors I and II, atrial natriuretic peptide, TGF-α, and amyloid peptides. Reported to be inversely correlated with brain Aβ peptide levels in insulysin-deficient mice compared to wild-type mice.
FormLiquid
FormulationIn 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.
Concentration Label Please refer to vial label for lot-specific concentration
EC number3.4.24.56
Purity≥90% by SDS-PAGE
Specific activity≥3 U/mg protein
Unit definitionOne unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.
Storage ≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesHersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.