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566661 InSolution™ Smoothened Agonist, SAG - Calbiochem

InSolution™ Smoothened Agonist, SAG, is a 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: SAG1.3 in Solution

566661
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₈H₂₈ClN₃OS • 2HCl • H₂O

Products

Número de referenciaEmbalaje Cant./Env.
566661-500UG Ampolla de plást. 500 μg
Description
Catalogue Number566661
Brand Family Calbiochem®
SynonymsSAG1.3 in Solution
References
ReferencesMeloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
Chen, W., et al. 2004. Science 306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
Product Information
FormLiquid
FormulationA 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.
Hill FormulaC₂₈H₂₈ClN₃OS • 2HCl • H₂O
Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • H₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
566661-500UG 04055977191585

Documentation

InSolution™ Smoothened Agonist, SAG - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

InSolution™ Smoothened Agonist, SAG - Calbiochem Certificados de análisis

CargoNúmero de lote
566661

Referencias bibliográficas

Visión general referencias
Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
Chen, W., et al. 2004. Science 306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-February-2009 JSW
SynonymsSAG1.3 in Solution
DescriptionA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
FormLiquid
FormulationA 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesMeloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
Chen, W., et al. 2004. Science 306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.