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444151 InSolution™ Nutlin-3, Racemic - Calbiochem

InSolution™ Nutlin-3, Racemic - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos:  MDM2 Inhibitor IV

444151
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₃₀H₃₀Cl₂N₄O₄

Products

Número de referenciaEmbalaje Cant./Env.
444151-1MG Ampolla de plást. 1 mg
Description
Catalogue Number444151
Brand Family Calbiochem®
Synonyms MDM2 Inhibitor IV
References
ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.
Product Information
FormLiquid
FormulationA 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Hill FormulaC₃₀H₃₀Cl₂N₄O₄
Chemical formulaC₃₀H₃₀Cl₂N₄O₄
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
444151-1MG 04055977205466

Documentation

InSolution™ Nutlin-3, Racemic - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

InSolution™ Nutlin-3, Racemic - Calbiochem Certificados de análisis

CargoNúmero de lote
444151

Referencias bibliográficas

Visión general referencias
Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-August-2008 JSW
Synonyms MDM2 Inhibitor IV
DescriptionA cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
FormLiquid
FormulationA 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₃₀Cl₂N₄O₄
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.