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420128 InSolution™ JNK Inhibitor II - Calbiochem

The InSolution™ JNK Inhibitor II, also referenced under CAS 129-56-6, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ JNK Inhibitor II - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: JNK 1, JNK 2, JNK 3
420128
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₄H₈N₂O

Products

Número de referenciaEmbalaje Cant./Env.
420128-5MG Ampolla de plást. 5 mg
Description
Catalogue Number420128
Brand Family Calbiochem®
References
ReferencesBennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
Product Information
ATP CompetitiveY
FormYellowish brown liquid
FormulationA 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
Hill FormulaC₁₄H₈N₂O
Chemical formulaC₁₄H₈N₂O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetJNK 1, JNK 2, JNK 3
Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
420128-5MG 04055977188066

Documentation

InSolution™ JNK Inhibitor II - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

InSolution™ JNK Inhibitor II - Calbiochem Certificados de análisis

CargoNúmero de lote
420128

Referencias bibliográficas

Visión general referencias
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-July-2008 RFH
DescriptionA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
FormYellowish brown liquid
FormulationA 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₈N₂O
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
Toxicity Irritant
ReferencesBennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
Han, Z., et al. 2001. J. Clin. Invest. 108, 73.