Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

508226 InSolution™ Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: protein phosphatase-2A & -1
508226
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
101932-71-2C₅₀H₈₁N₄O₁₅P

Products

Número de referenciaEmbalaje Cant./Env.
5082260001 Frasco de vidrio 5 μg
Description
Catalogue Number508226
Brand Family Calbiochem®
References
ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
Product Information
CAS number101932-71-2
FormLiquid
FormulationA 100 µM (5 µg/50 µL) sterile-filtered solution of Calyculin A, Discodermia calyx (Cat. No. 208851) in DMSO.
Hill FormulaC₅₀H₈₁N₄O₁₅P
Chemical formulaC₅₀H₈₁N₄O₁₅P
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetprotein phosphatase-2A & -1
Primary Target IC<sub>50</sub>0.5-1.0 and 2 nM for PP2A and PP1, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
5082260001 04055977261776

Documentation

InSolution™ Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referencias
Murakami, N., et al. 1994. Neurosci. Lett. 176, 181.
Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
DescriptionCell-permeable protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca2+-activated K+ channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent γ-radiation induced apoptosis in Burkitt's lymphoma cell line BM13674.
FormLiquid
FormulationA 100 µM (5 µg/50 µL) sterile-filtered solution of Calyculin A, Discodermia calyx (Cat. No. 208851) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number101932-71-2
Chemical formulaC₅₀H₈₁N₄O₁₅P
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
Toxicity Standard Handling
ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.