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196871 InSolution™ BAY 11-7082 - Calbiochem

InSolution™ BAY 11-7082 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: TNF-α-inducible phosphorylation of IκBα
196871
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₀H₉NO₂S

Products

Número de referenciaEmbalaje Cant./Env.
196871-10MG Ampolla de plást. 10 mg
Description
Catalogue Number196871
Brand Family Calbiochem®
References
ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
Product Information
ATP CompetitiveN
FormLiquid
FormulationSupplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.
Hill FormulaC₁₀H₉NO₂S
Chemical formulaC₁₀H₉NO₂S
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-α-inducible phosphorylation of IκBα
Primary Target IC<sub>50</sub>10 µM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
196871-10MG 04055977206579

Documentation

InSolution™ BAY 11-7082 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

InSolution™ BAY 11-7082 - Calbiochem Certificados de análisis

CargoNúmero de lote
196871

Referencias bibliográficas

Visión general referencias
Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

Citas

Título
  • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
  • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•
    Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-April-2008 RFH
    DescriptionPotential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
    FormLiquid
    FormulationSupplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₁₀H₉NO₂S
    Structure formulaStructure formula
    Purity≥95% by HPLC
    Storage Protect from light
    +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Toxicity Irritant
    ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
    Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
    Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
    Citation
  • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
  • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•