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124017 InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem

InSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a 10 mM solution in DMSO. A cell-permeable, reversible, selective inhibitor of Akt1 & Akt2 (IC50 = 58 nM & 210 nM).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: Akt1, Akt2, Akt3
124017
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₃₄H₂₉N₇O

Products

Número de referenciaEmbalaje Cant./Env.
124017-1MG Ampolla de plást. 1 mg
Description
Catalogue Number124017
Brand Family Calbiochem®
References
ReferencesBarnett, S.F., et al. 2005. Biochem. J. 385, 399.
DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
Hill FormulaC₃₄H₂₉N₇O
Chemical formulaC₃₄H₂₉N₇O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a 10 mM solution in DMSO. A cell-permeable, reversible, selective inhibitor of Akt1 & Akt2 (IC50 = 58 nM & 210 nM).
Biological Information
Primary TargetAkt1, Akt2, Akt3
Primary Target IC<sub>50</sub>58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays
Purity≥95% by HPLC
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
124017-1MG 07790788047993

Documentation

InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem Certificados de análisis

CargoNúmero de lote
124017

Referencias bibliográficas

Visión general referencias
Barnett, S.F., et al. 2005. Biochem. J. 385, 399.
DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.

Folleto

Cargo
Akt
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-August-2011 RFH
DescriptionA cell-permeable, potent, and selective inhibitor of Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 µM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo.
FormLiquid
FormulationA 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Concentration Label Please refer to vial label for lot-specific concentration
Chemical formulaC₃₄H₂₉N₇O
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Irritant
ReferencesBarnett, S.F., et al. 2005. Biochem. J. 385, 399.
DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.