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124038 InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

The InSolution™ Akt Inhibitor V, Triciribine, also referenced under CAS 35943-35-2, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
124038
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
35943-35-2C₁₃H₁₆N₆O₄

Products

Número de referenciaEmbalaje Cant./Env.
124038-2MG Frasco de vidrio 2 mg
Description
OverviewA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
Catalogue Number124038
Brand Family Calbiochem®
References
ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
Yang, L., et al. 2004. Cancer Res. 64, 4394.
Product Information
CAS number35943-35-2
FormLiquid
FormulationA 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
Hill FormulaC₁₃H₁₆N₆O₄
Chemical formulaC₁₃H₁₆N₆O₄
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRY8455000
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing intitial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
124038-2MG 04055977205848

Documentation

InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Certificados de análisis

CargoNúmero de lote
124038

Referencias bibliográficas

Visión general referencias
Karst, A., et al. 2006. Cancer Res. 66, 9225.
Yang, L., et al. 2004. Cancer Res. 64, 4394.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-January-2012 RFH
DescriptionA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
FormLiquid
FormulationA 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number35943-35-2
RTECSRY8455000
Chemical formulaC₁₃H₁₆N₆O₄
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing intitial thaw, aliquot and freeze (-70°C).
Toxicity Irritant
ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
Yang, L., et al. 2004. Cancer Res. 64, 4394.