Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

CC1019 Human Integrin αVβ3, Triton X-100 Formulation

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Key Applications: Positive Control UniProt Number: P06756 Entrez Gene Number: NM_002210.2
CC1019
50 µg  
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue NumberCC1019
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionHuman Integrin αVβ3, Triton X-100 Formulation
OverviewIntegrin alphaVbeta3 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to aVb3 integrin. A tissue detergent extract, which was applied to the column was prepared as previously described (Belkin, 1990).
Alternate Names
  • CD51/CD61
References
Product Information
PresentationPurified protein in 20 mM Tris-HCI, pH 7.5, 150 mM NaCI, 2 mM MgCI2, 0.2% Triton X-100. No preservatives.
Quality LevelMQ100
Applications
Key Applications
  • Positive Control
Application NotesElectrophoresis and Immunoblotting control. Also useful for in vitro binding experiments with metalloproteinase MMP-2.

Optimal working dilutions must be determined by end user.
Biological Information
Concentration0.2 mg/mL
Purity> 95% pure by gel analysis. Nonreduced 7.5% PAAG stained with Silver stain shows major bands at 92 kDa (beta3 subunit), 145 kDa (alphaV subunit) and a minor band at 170 kDa (beta3 subunit dimer).
Specific ActivityFunctional activity confirmed by interaction of integrin alphaV/beta3 with vitronectin, von Willebrand Factor, fibrinogen, and fibronectin in RGD-dependent ELISA testing.
Entrez Gene Number
Entrez Gene SummaryITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
Gene Symbol
  • ITGAV
  • DKFZp686A08142
  • MSK8
  • CD51
  • VNRA
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -70°C in undiluted aliquots. Avoid repeated freeze/ thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
CC1019 04053252620584

Documentation

Human Integrin αVβ3, Triton X-100 Formulation Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Human Integrin αVβ3, Triton X-100 Formulation Certificados de análisis

CargoNúmero de lote
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION PURIFIED PROTEIN - 2062290 2062290
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION PURIFIED PROTEIN - 2421796 2421796
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION - 3527817 3527817
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION - 3610587 3610587
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION - 3771066 3771066
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION - 4073650 4073650
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION -2660248 2660248
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION -2676254 2676254
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION PURIFIED PROTEIN 3091682
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION PURIFIED PROTEIN 3052591
Show more

Ficha técnica

Cargo
HUMAN INTEGRIN alphaVbeta3 TRITON X-100 FORMULATION PURIFIED PROTEIN