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382190 Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem

The Histone Lysine Methyltransferase Inhibitor, also referenced under CAS 935693-62-2, controls the biological activity of Histone Lysine Methyltransferase. This small molecule/inhibitor is primarily used for Cancer applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: HMTase Inhibitor, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-(1-(phenylmethyl)-4-piperidinyl)-4-quinazolinamine, BIX-01294, EHMT2/G9a Inhibitor I

382190
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
935693-62-2C₂₈H₃₈N₆O₂

Products

Número de referenciaEmbalaje Cant./Env.
382190-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable diazepinyl-quinazolinamine, non-SAM (S-adenosylmethionine) analog-based HMTase (histone methyltransferase) inhibitor that selectively interferes with the G9a-catalyzed H3K9me2 (histone H3 Lys9 dimethylation) modification (IC50 = 1.7 µM) in a reversible manner. It inhibits the GLP-catalyzed H3K9me3 only at much higher concentrations (IC50 = 38 µM) and exhibits little activity against H3 methylations catalyzed by other HMTases (PRMT1, SET7/9, ESET, SUV39H1). Shown to effectively synergize with Oct3/4 and Klf4 in inducing reprogramming of primary murine fetal NPCs (Neural Progenitor Cells) into iPS (induced Pluripotent Stem) cells without additional viral transduction of Sox2 and c-Myc.
Catalogue Number382190
Brand Family Calbiochem®
SynonymsHMTase Inhibitor, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-(1-(phenylmethyl)-4-piperidinyl)-4-quinazolinamine, BIX-01294, EHMT2/G9a Inhibitor I
References
ReferencesShi, Y., et al. 2008. Cell Stem Cell 2, 525.
Kubicek, S., et al. 2007. Mol. Cell 25, 473.
Product Information
CAS number935693-62-2
FormOff-white solid
Hill FormulaC₂₈H₃₈N₆O₂
Chemical formulaC₂₈H₃₈N₆O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
382190-5MG 04055977212877

Documentation

Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem Certificados de análisis

CargoNúmero de lote
382190

Referencias bibliográficas

Visión general referencias
Shi, Y., et al. 2008. Cell Stem Cell 2, 525.
Kubicek, S., et al. 2007. Mol. Cell 25, 473.

Licencias necesarias e Información técnica

Cargo
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-November-2009 RFH
SynonymsHMTase Inhibitor, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-(1-(phenylmethyl)-4-piperidinyl)-4-quinazolinamine, BIX-01294, EHMT2/G9a Inhibitor I
DescriptionA cell-permeable diazepinyl-quinazolinamine, non-SAM (S-adenosylmethionine) analog-based HMTase (histone methyltransferase) inhibitor that selectively interferes with the G9a-catalyzed H3K9me2 (histone H3 Lys9 dimethylation) modification (IC50 = 1.7 µM) in a reversible manner. It inhibits the GLP-catalyzed H3K9me3 only at much higher concentrartions (IC50 = 38 µM) and exhibits little activity against H3 methylations catalyzed by other HMTases (PRMT1, SET7/9, ESET, SUV39H1). Shown to effectively synergize with Oct3/4 and Klf4 in inducing reprogramming of primary murine fetal NPCs (Neural Progenitor Cells) into iPS (induced Pluripotent Stem) cells without additional viral transduction of Sox2 and c-Myc.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number935693-62-2
Chemical formulaC₂₈H₃₈N₆O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesShi, Y., et al. 2008. Cell Stem Cell 2, 525.
Kubicek, S., et al. 2007. Mol. Cell 25, 473.