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382120 Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem

The Histone Acetyltransferase Activator, CTB, also referenced under CAS 451491-47-7, modulates the biological activity of Histone. This small molecule/inhibitor is primarily used for Cell Structure applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator

382120
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
451491-47-7C₁₆H₁₃ClF₃NO₂

Products

Número de referenciaEmbalaje Cant./Env.
382120-25MG Ampolla de plást. 25 mg
Description
OverviewA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
Catalogue Number382120
Brand Family Calbiochem®
SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
References
ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
Product Information
CAS number451491-47-7
FormOff-white solid
Hill FormulaC₁₆H₁₃ClF₃NO₂
Chemical formulaC₁₆H₁₃ClF₃NO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
382120-25MG 04055977213133

Documentation

Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem Certificados de análisis

CargoNúmero de lote
382120

Referencias bibliográficas

Visión general referencias
Mantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-September-2017 JSW
SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
DescriptionA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number451491-47-7
Chemical formulaC₁₆H₁₃ClF₃NO₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityEthanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.