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376817 Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem

The Hexokinase II Inhibitor II, 3-BP, also referenced under CAS 1113-59-3, controls the biological activity of Hexokinase II. This small molecule/inhibitor is primarily used for Cell Structure applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid

376817
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
1113-59-3C₃H₃BrO₃

Products

Número de referenciaEmbalaje Cant./Env.
376817-100MG 100 mg
Description
OverviewA cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.
Catalogue Number376817
Brand Family Calbiochem®
Synonyms3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid
References
ReferencesBujis, M., et al. 2009. Invest. New Drugs 27, 120.
Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
Hulleman, E., et al. 2009. Blood. 113, 2014;
Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
Yun, J., et al. 2009. Science. 325, 1555.
Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.
Product Information
CAS number1113-59-3
EC number214-206-5
FormWhite crystalline solid
Hill FormulaC₃H₃BrO₃
Chemical formulaC₃H₃BrO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by Titration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUZ0840000
Safety Information
R PhraseR: 34

Causes burns.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Corrosive
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
376817-100MG 04055977212983

Documentation

Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem Certificados de análisis

CargoNúmero de lote
376817

Referencias bibliográficas

Visión general referencias
Bujis, M., et al. 2009. Invest. New Drugs 27, 120.
Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
Hulleman, E., et al. 2009. Blood. 113, 2014;
Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
Yun, J., et al. 2009. Science. 325, 1555.
Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-December-2010 RFH
Synonyms3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid
DescriptionA cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.
FormWhite crystalline solid
CAS number1113-59-3
RTECSUZ0840000
EC number214-206-5
Chemical formulaC₃H₃BrO₃
Structure formulaStructure formula
Purity≥97% by Titration
SolubilityDMSO (100 mg/ml) or dH₂O (100 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Corrosive
ReferencesBujis, M., et al. 2009. Invest. New Drugs 27, 120.
Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
Hulleman, E., et al. 2009. Blood. 113, 2014;
Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
Yun, J., et al. 2009. Science. 325, 1555.
Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.