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SCC163 HOG Human Oligodendroglioma Cell Line

HOG human oligodendroglioma cell line is a useful model to study the role of oligodendrocytes in neurodegenerative diseases.

SCC163
≥1X10⁶ cells/vial   
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Descripción

Replacement Information
Description
Catalogue NumberSCC163
DescriptionHOG Human Oligodendroglioma Cell Line
Background InformationHOG is a clonal cell line derived from a surgically removed human oligodendroglioma (HOG) (1). HOG cells express oligodendrocyte markers including low levels of the 15-kDa form of myelin basic protein (MBP) and high levels of CNPase protein. HOG cells do not express GFAP, a astrocyte marker and were found to have minimal levels of glutamine synthetase activity (1,3,4). HOG cells express neurotransmitter receptors such as A2-adenosine, prostaglandin E1 (PGE1) and beta2-adrenergic receptores (beta-ARs) that activate the adenylate cylase signaling pathway (1). HOG cells also express muscarinic and histamine receptors that are linked to inositol phosphate signaling pathways (1, 2).

References
1. Post GR, Dawson G (1992) Characterization of a cell line derived from a human oligodendroglioma. Mol Chem Neuropathol 16(3): 303-317.
2. Post GR, Dawson G (1992) Regulation of carbachol- and histamine-induced inositol phospholipid hydrolysis in a human oligodendroglioma. Glia 5(2): 122-130.
3. Buntinx M, et al. (2003) Characterization of three human oligodendroglial cell lines as a model to study oligodendrocyte injury: morphology and oligodendrocyte-specific gene expression. J Neurocytol 32(1): 25-38.
4. De Vries GH, Boullerne AI (2010) Glial cell lines: an overview. Neurochem Res 35(12): 1978-200
References
Product Information
Applications
ApplicationHOG human oligodendroglioma cell line is a useful model to study the role of oligodendrocytes in neurodegenerative diseases.
Key Applications
  • Cell Culture
  • Cell Based Assays
Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
Biological Information
Cell Line Type
  • Cancer Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, C, and HIV-1 & 2 viruses as assessed by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Packaging Information
Material Size≥1X10⁶ cells/vial
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
SCC163 04054839478970

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