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370677 Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem

370677
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N

Products

Número de referenciaEmbalaje Cant./Env.
370677-1UMOL Ampolla de plást. 1 umol
Description
OverviewA potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.
Catalogue Number370677
Brand Family Calbiochem®
SynonymsRp-8-pCPT-cGMPS, TEA, PKG Inhibitor III
References
ReferencesAbd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.
Product Information
ATP CompetitiveN
DeclarationSold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.
FormLyophilized
Hill FormulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
Chemical formulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKG1α
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
370677-1UMOL 04055977191707

Documentation

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem Certificados de análisis

CargoNúmero de lote
370677

Referencias bibliográficas

Visión general referencias
Abd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-July-2008 RFH
SynonymsRp-8-pCPT-cGMPS, TEA, PKG Inhibitor III
DescriptionA potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.
FormLyophilized
Chemical formulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO or H₂O (0.5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAbd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.