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356310 Glyburide - CAS 10238-21-8 - Calbiochem

A sulfonylurea that selectively blocks ATP-sensitive K+ channels.

Glyburide - CAS 10238-21-8 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Glybenclamide

Primary Target: ATP-sensitive K+ channels
356310
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
10238-21-8C₂₃H₂₈ClN₃O₅S

Products

Número de referenciaEmbalaje Cant./Env.
356310-1GM Ampolla de plást. 1 gm
Description
OverviewA sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. Inhibits the vasorelaxing effects of nitric oxide.
Catalogue Number356310
Brand Family Calbiochem®
SynonymsGlybenclamide
References
ReferencesHolzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.
Product Information
CAS number10238-21-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₂₈ClN₃O₅S
Chemical formulaC₂₃H₂₈ClN₃O₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetATP-sensitive K+ channels
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYS4725200
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
356310-1GM 04055977192711

Documentation

Glyburide - CAS 10238-21-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Glyburide - CAS 10238-21-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
356310

Referencias bibliográficas

Visión general referencias
Holzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-May-2008 RFH
SynonymsGlybenclamide
DescriptionAntidiabetic sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. High-affinity binding sites are widely distributed and have been identified in the cardiovascular system, the central nervous system, and pancreatic β-cells. In cultured cells, glyburide enhances insulin action and stimulates the synthesis of glucose transporters. Displays large potency difference in action on pancreatic tissue (IC50 in nM range) and vascular tissue (IC50 in µM range).
FormWhite solid
CAS number10238-21-8
RTECSYS4725200
Chemical formulaC₂₃H₂₈ClN₃O₅S
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mg/ml) or Ethanol (5 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 4478
ReferencesHolzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.