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351801 Glucose Transporter Inhibitor III, STF-31 - Calbiochem

The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: STF-31

351801
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₃H₂₅N₃O₃S

Products

Número de referenciaEmbalaje Cant./Env.
351801-10MG Frasco de vidrio 10 mg
Description
OverviewA cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.
Catalogue Number351801
Brand Family Calbiochem®
SynonymsSTF-31
References
ReferencesChan, D., et al. 2011. Sci. Transl. Med. 3, 94ra70.
Product Information
FormWhite solid
Hill FormulaC₂₃H₂₅N₃O₃S
Chemical formulaC₂₃H₂₅N₃O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
351801-10MG 04055977193220

Documentation

Glucose Transporter Inhibitor III, STF-31 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Glucose Transporter Inhibitor III, STF-31 - Calbiochem Certificados de análisis

CargoNúmero de lote
351801

Referencias bibliográficas

Visión general referencias
Chan, D., et al. 2011. Sci. Transl. Med. 3, 94ra70.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-July-2012 JSW
SynonymsSTF-31
DescriptionA cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₂₅N₃O₃S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChan, D., et al. 2011. Sci. Transl. Med. 3, 94ra70.