Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

345885 GGTI-2147 - CAS 191102-87-1 - Calbiochem

A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).

GGTI-2147 - CAS 191102-87-1 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester

Primary Target: GGTase-I
345885
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
191102-87-1C₂₈H₃₀N₄O₃

Products

Número de referenciaEmbalaje Cant./Env.
345885-250UG Ampolla de plást. 250 μg
Description
OverviewA cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50 value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 > 30 µM for H-Ras).
Catalogue Number345885
Brand Family Calbiochem®
Synonyms4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
References
ReferencesBernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.
Product Information
CAS number191102-87-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₈H₃₀N₄O₃
Chemical formulaC₂₈H₃₀N₄O₃
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGGTase-I
Primary Target IC<sub>50</sub>500 nM in blocking the geranyl-geranylation of Rap1A
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
345885-250UG 04055977214529

Documentation

GGTI-2147 - CAS 191102-87-1 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

GGTI-2147 - CAS 191102-87-1 - Calbiochem Certificados de análisis

CargoNúmero de lote
345885

Referencias bibliográficas

Visión general referencias
Bernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
Synonyms4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
DescriptionMethyl ester derivative of GGTI-2133 (Cat. No. 345884). A potent and selective non-thiol inhibitor of geranylgeranyltransferase I (GGTase I) over farnesyltransferase (FTase) in whole cells. Blocks the geranylgeranylation of Rap1A with an IC50 value greater than 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 <30 µM for H-Ras).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number191102-87-1
Chemical formulaC₂₈H₃₀N₄O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.