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14-820M Fms (Y969C) Protein, active, 250 µg

Active, N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end containing the mutation Y969C. For use in Kinase Assays.

14-820M
250 µg  Also available in 10 μg size (cat#14-820) and in bulk (cat# 14-820-K).
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-820M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionFms (Y969C) Protein, active, 250 µg
OverviewN-terminal His6-tagged, recombinant, human Fms, amino acids 538-end containing the mutation Y969C.
References
Product Information
Presentation50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Quality LevelMQ300
Applications
ApplicationActive, N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end containing the mutation Y969C. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
Gene Symbol
  • CSF1R
  • FIM2
  • CSF-1-R
  • C-FMS
  • CSFR
  • c-fms
  • CD115
  • FMS
Protein TargetFms
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
Molecular Weight50.2kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-820) and in bulk (cat# 14-820-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-820M 04053252275593

Documentation

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Alternative Packsize

Número de referencia Descripción
14-820 Fms (Y969C) Protein, active, 10 µg

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Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases