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341205 Etoposide - CAS 33419-42-0 - Calbiochem

Etoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.

Etoposide - CAS 33419-42-0 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: VP-16

Primary Target: topoisomerase 2
341205
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Descripción

Tabla espec. clave

CAS #Empirical Formula
33419-42-0C₂₉H₃₂O₁₃

Products

Número de referenciaEmbalaje Cant./Env.
341205-25MG Ampolla de plást. 25 mg
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Description
OverviewA cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
Catalogue Number341205
Brand Family Calbiochem®
SynonymsVP-16
References
ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
Product Information
CAS number33419-42-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₃₂O₁₃
Chemical formulaC₂₉H₃₂O₁₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationEtoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.
Biological Information
Primary Targettopoisomerase 2
Primary Target IC<sub>50</sub>59.2 µM inhibiting topoisomerase II
Purity>95% by HPLC
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSKC0190000
Safety Information
R PhraseR: 22-45

Harmful if swallowed.
May cause cancer.
S PhraseS: 26-36/37/39-45-53

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Número de referencia GTIN
341205-25MG 04055977215434