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14-644M EphA3 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end. For use in Kinase Assays.

14-644M
250 µg  Also available in 10 μg size (cat#14-644) and in bulk (cat#14-644-K).
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-644M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionEphA3 Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceHuman EphA3 amino acids 578-end, expressed by baculovirus in Sf21 insect cells.
Entrez Gene Number
Entrez Gene SummaryThis gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.
Gene Symbol
  • EPHA3
  • HEK4
  • ETK1
  • HEK
  • TYRO4
  • ETK
  • EphA3
Protein TargetEphA3
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P29320 # Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.
SIZE: 983 amino acids; 110131 Da
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Widely expressed. Highest level in placenta.
DISEASE:SwissProt: P29320 # Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].
SIMILARITY: SwissProt: P29320 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
Molecular Weight49kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-644) and in bulk (cat#14-644-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-644M 04053252924521

Documentation

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Alternative Packsize

Número de referencia Descripción
14-644 EphA3 Protein, active, 10 µg

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Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases