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05-23-3800 Sigma-AldrichEndothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.

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Certificado de análisis (CoA)
Referencias bibliográficas
Data Sheet

Sinónimos: ET-1, CSCSSLMDKECVYFCHLDIIW

Primary Target: Potent vasoconstrictive action

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Descripción

Tabla espec. clave

CAS #	Empirical Formula
117399-94-7	C₁₀₉H₁₅₉N₂₅O₃₂S₅

Products

Número de referencia	Embalaje	Cant./Env.
05-23-3800-0.1MG	Ampolla de plást.	.1 mg	Añadir a favoritos Añadir a favoritos Añadido a Mis favoritos
05-23-3800-0.5MG	Ampolla de plást.	.5 mg	Añadir a favoritos Añadir a favoritos Añadido a Mis favoritos
05-23-3800-1MG	Ampolla de plást.	1 mg	Añadir a favoritos Añadir a favoritos Añadido a Mis favoritos

Description
Overview	A 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca²⁺ channels. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.
Catalogue Number	05-23-3800
Brand Family	Calbiochem®
Synonyms	ET-1, CSCSSLMDKECVYFCHLDIIW

References
References	Cesari, M., et al. 1996. Am. Heart J. 132, 1236. Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169. Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524. Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294. Itoh, Y., et al. 1988. FEBS Lett. 231, 440. Yanagisawa, M., et al. 1988. Nature 332, 411.

Product Information
CAS number	117399-94-7
ATP Competitive	N
Form	White to off-white solid
Formulation	Supplied as an acetate salt.
Hill Formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Chemical formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Reversible	N
Sold on the basis of peptide content	Y
Quality Level	MQ100

Biological Information
Primary Target	Potent vasoconstrictive action
Purity	≥96% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Content	Y
Peptide Sequence	H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Global Trade Item Number
Número de referencia	GTIN
05-23-3800-0.1MG	04055977226775
05-23-3800-0.5MG	04055977226782
05-23-3800-1MG	04055977226799

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